The Church of the Nazarene is the largest denomination in the classical Wesleyan-Holiness tradition. The doctrine that distinguishes the Church of the Nazarene and other Wesleyan denominations from most other Christian denominations is that of entire sanctification. Nazarenes believe that God calls Christians to a life of holy living that is marked by a second work of God's grace, that cleanses the heart from original sin and fills the individual with love for God and humankind.